Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
Yisui Granule
- Development stage
- Phase 1
- Lead developer
- Xiyuan Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Yisui Granule (YSG) is a Traditional Chinese Medicine (TCM) formulation developed primarily for the treatment of myelodysplastic syndromes (MDS), particularly low and medium-risk categories. Its therapeutic mechanism is characterized by epigenetic modulation, specifically acting as a demethylating agent. Research indicates that YSG reduces the expression of DNA methyltransferase 1 (DNMT1), which leads to the demethylation and subsequent reactivation of the secreted frizzled-related protein 5 (sFRP5) gene. Reactivation of sFRP5 functions as an antagonist to the Wnt/β-catenin signaling pathway, effectively down-regulating oncogenic components such as Wnt3a, β-catenin, c-Myc, and cyclinD1. This suppression of abnormal signaling pathways contributes to anti-tumor effects and improved hematopoiesis, offering a potential alternative or adjunctive therapy to standard hypomethylating agents like decitabine.
- Brand names
- Yisui Granule
- Other names
- Yisui granuleYisui-granule
02
Targets
CTNNB1 (Beta-catenin)SFRP5 (Secreted frizzled-related protein 5)DNMT1 (DNA (cytosine-5)-methyltransferase 1)
Beyond the preview
Go deeper on Yisui Granule.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Yisui Granule.