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YMN-A03
- Development stage
- Phase 1
- Lead developer
- West China Hospital of Sichuan University
- Modality
- Nanobodies (VHH) → Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics, Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
- Administration
- Inhalation
01
Overview
YMN-A03 is a novel, nebulized bifunctional fusion protein consisting of a nanobody (VHH) targeting programmed cell death 1 ligand 1 (PD-L1) fused to interleukin-15 (IL-15). Developed by West China Hospital of Sichuan University, it is designed for local delivery to the lungs via inhalation to treat advanced non-small cell lung cancer (NSCLC). By targeting PD-L1, YMN-A03 blocks the PD-1/PD-L1 checkpoint pathway, while the IL-15 component promotes the activation and proliferation of T cells and natural killer (NK) cells within the tumor microenvironment. The nebulized formulation aims to achieve high local concentrations in the lung while minimizing systemic toxicity. It is currently being evaluated in Phase I clinical trials for patients with advanced NSCLC who have progressed after standard systemic therapies.
- Other names
- YMN-A03YMN-A-03YMN-A 03
02
Targets
IL-15R (Interleukin 15 receptor alpha/interleukin 15 complex)CD274 (Programmed cell death protein 1 ligand 1)PDCD1LG2 (Programmed cell death 1 ligand 2)
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