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YMN-V115
- Development stage
- Unknown
- Lead developer
- West China Hospital of Sichuan University
- Modality
- mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Vaccines & Immunotherapeutics
- Administration
- Subcutaneous
01
Overview
YMN-V115 is a personalized neoantigen mRNA vaccine being developed by West China Hospital, Sichuan University, in collaboration with Chengdu Yuman Biotechnology. It is designed to elicit a patient-specific T-cell response against unique tumor mutations (neoantigens) identified through genomic sequencing of the patient's tumor. The vaccine is administered subcutaneously and is currently being evaluated in a Phase 1 clinical trial (ChiCTR2600123828) in combination with the PD-1 inhibitor treliplimab for the treatment of advanced melanoma in patients who have progressed after prior anti-PD-1 immunotherapy and targeted therapy where applicable.
- Other names
- YMN-V115YMN-V-115YMN-V 115
02
Targets
BCMA (B-cell maturation antigen)CD3 (T-cell surface glycoprotein CD3)GPRC5D
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