Drug intelligence / Profile preview

Yogaraja Guggulu

Development stage
Unknown
Lead developer
University of Colombo
Administration
Oral
01

Overview

Yogaraja Guggulu is a traditional multi-ingredient Ayurvedic and Sri Lankan traditional medicine (STM) herbal formulation primarily used to treat musculoskeletal and joint disorders, such as knee osteoarthritis (referred to as 'Sandhigata Vata' in traditional systems) and rheumatoid arthritis. It is a complex botanical mixture containing guggulu resin (*Commiphora mukul*) combined with various synergistic herbs (such as ginger, black pepper, and long pepper) that possess anti-inflammatory, analgesic, and antioxidant properties. In clinical trials, such as those sponsored by the University of Colombo, Yogaraja Guggulu is administered orally as part of a multi-component regimen alongside the Rasnadvigunabhagasaya (RDBD) herbal decoction and external preparations to manage pain and stiffness in patients with knee osteoarthritis.

Other names
Yograj GuggulYogaraja GulguluYogaraja Guggulu Pill
02

Targets

FXR (Farnesoid x-activated receptor)ALOX12 (Arachidonate 12-lipoxygenase, 12S type)ABCB11 (Bile salt export pump)AR (Adrenergic receptors)GR (Glucocorticoid receptor)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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