Yonsei Univ. College of Medicine SDHC compound 17

Yonsei Univ. College of Medicine SDHC compound 17: sourced facts only. name: "Mechanistic studies showed that both 10 and 17 inhibit SDHC activity, reduce CII-specific oxygen consumption rates (OCR), and induce increased ROS production, leading to apoptosis." [PMID:40882437]; target: "Mechanistic studies showed that both 10 and 17 inhibit SDHC activity, reduce CII-specific oxygen consumption rates (OCR), and induce increased ROS production, leading to apoptosis." [PMID:40882437]; developer: "Department of Biomedical Sciences, Graduate School of Medical Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea." [PMID:40882437]; stage: "Furthermore, in patient-derived organoid (PDO) models, derivative 10 (GA265T GI50 = 5.623 μM) and 17 (GA265T GI50 = 6.347 μM) exhibited enhanced anti-proliferative activity in SEM-type GC PDOs (SDHC-high) compared to non-SEM-type PDOs (SDHC-low), with over a 2-fold increase in anti-proliferative activity against the GA265T SEM-type PDO model compared to α-TOS (6; GA265T GI50 = 12.660 μM)." [PMID:40882437]