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YR-G274

Development stage: Preclinical
Lead developer: Sichuan Enray Pharmaceutical Sciences
Modality: Small Molecules

Overview

YR-G274 is a preclinical small molecule glutathione peroxidase 4 (GPX4) inhibitor being developed by Sichuan Enray Pharmaceutical Sciences. As a derivative of YR-G346, YR-G274 is designed to target the selenocysteine active site of the GPX4 protein, thereby blocking the glutathione regeneration pathway and preventing the detoxification of lipid hydroperoxides. This mechanism leads to the accumulation of lethal lipid peroxides and significantly increases the sensitivity of tumor cells to ferroptosis, offering a potential therapeutic strategy for the treatment of advanced solid tumors.

Targets

GPX4 (Glutathione peroxidase 4)

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