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YRA-1909
- Development stage
- Phase 2
- Lead developer
- Yungjin Pharm
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
YRA-1909 is a botanical drug candidate developed by Yungjin Pharm for the treatment of rheumatoid arthritis (RA). It is a standardized extract derived from the plants *Lonicera japonica* (honeysuckle) and *Anemarrhena asphodeloides*. The drug is designed to modulate the immune response by suppressing the production of key pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), which play central roles in the pathogenesis of RA. YRA-1909 is currently being evaluated in Phase 2 clinical trials as an adjunctive therapy for patients who have had an inadequate response to methotrexate (MTX-IR).
02
Targets
TNFA (Tumor necrosis factor alpha (soluble))IL-6 (Interleukin 6)
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