YS121

YS121 is a **small molecule dual inhibitor** of **microsomal prostaglandin E2 synthase-1 (mPGES-1)** and **5-lipoxygenase (5-LOX)**. It displays inhibitory activity with IC50 values of 3.4 μM for mPGES-1 and 6.5 μM for 5-LOX. YS121 has been studied primarily for its **anti-inflammatory effects**, and is under preclinical investigation as a drug candidate for the treatment or prevention of conditions involving inflammation, such as polycystic kidney disease[1][3][5]. The compound was initially developed by Eberhard Karls Universität Tübingen. Its structure is described as 2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid (C20H26ClN3O2S)[3].

Other names

2-(4-chloro-6-(2,3-dimethylphenylamino)pyrimidin-2-ylthio)octanoic acid