Drug intelligence / Profile preview

yttrium-90 chloride

Development stage
Unknown
Lead developer
Chengdu New Radiomedicine Technology
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration
Intraarticular, Intratumoral, Intra-arterial, Parenteral
01

Overview

Yttrium-90 chloride solution is a therapeutic radiopharmaceutical precursor containing the radionuclide yttrium-90 (Y-90). Y-90 is a high-energy beta-emitting isotope with a half-life of approximately 64.1 hours. It is primarily utilized as a raw material for the radiolabeling of various therapeutic agents, including monoclonal antibodies, peptides, and microspheres, for targeted radionuclide therapy. Additionally, the solution is used directly in clinical applications such as radiosynovectomy for the treatment of chronic inflammatory joint diseases. The beta radiation emitted by Y-90 has a maximum energy of 2.28 MeV and a mean tissue penetration depth of 2.5 mm, which allows for localized cytotoxic effects on tumor cells or inflamed synovial tissue while minimizing damage to surrounding healthy structures. Chengdu New Radiomedicine Technology is a major developer and large-scale manufacturer of this isotope solution, maintaining significant production capacity for clinical and research applications.

Other names
yttrium-90 chloride solutionyttrium90 chloride solutionyttrium 90 chloride solutionY-90 chloride solutionY90 chloride solutionY 90 chloride solutionyttrium (90Y) chloride[90Y]YCl3
02

Targets

DNA

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