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yttrium Y 90 monoclonal antibody Hu3S193
- Development stage
- Phase 1
- Lead developer
- Ludwig Cancer Research
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intraperitoneal, Intravenous
01
Overview
**Yttrium Y 90 monoclonal antibody Hu3S193** is an investigational Lewis Y-targeted radioimmunotherapeutic consisting of the humanized IgG1 monoclonal antibody hu3S193 chelated to the beta-emitting radionuclide yttrium-90. It binds the tumor-associated Lewis Y carbohydrate antigen on epithelial malignancies and selectively deposits cytotoxic beta radiation in antigen-expressing tumors and adjacent cells, causing radiation-mediated cellular injury. The agent was developed by Ludwig Cancer Research and evaluated in a completed phase 1 intraperitoneal dose-escalation study in advanced ovarian epithelial cancer; it also showed antitumor activity in Lewis Y-positive breast-cancer xenograft studies. ([cancer.gov](https://www.cancer.gov/publications/dictionaries/cancer-drug/def/yttrium-y-90-monoclonal-antibody-hu3s193))
- Other names
- 90Y-hu3S193Y90 MOAB Hu3S193Y-90 MOAB Hu3S193Y 90 MOAB Hu3S193
02
Targets
LeY (Lewis Y antigen)
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