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Yuanhu Zhitong dispersible tablets
- Development stage
- Unknown
- Lead developer
- Chengdu Yongkon Pharmacy
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Yuanhu Zhitong dispersible tablets is an approved traditional Chinese medicine (TCM) formulation developed by Chengdu Yongkon Pharmacy (a subsidiary of Tonghua Golden Horse) for the treatment of stomach pain, hypochondriac pain, headache, and dysmenorrhea associated with qi stagnation and blood stasis. The formulation is composed of two primary herbal ingredients: Rhizoma Corydalis (Yuanhu) and Radix Angelicae Dahuricae (Baizhi). The active constituents, including alkaloids like tetrahydropalmatine and protopine, exert analgesic, anti-inflammatory, and spasmolytic effects. These effects are mediated through multi-target interactions, including the antagonism of dopamine D2 receptors and muscarinic M2 receptors, as well as the activation of 5-HT1A, mu-opioid, and beta-2 adrenergic receptors.
- Brand names
- Tongdingsitong痛定思痛
- Other names
- Yuan Hu Zhi Tong Fen San TabletsYuanhu Zhitong Dispersible Tablets元胡止痛分散片
02
Targets
CHRM2 (Muscarinic acetylcholine receptor M2)DRD2 (Dopamine D2 Receptor)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))MOR (Mu opioid receptor)
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