Drug intelligence / Profile preview

Yuhudie Melasma Ointment

Development stage
Unknown
Lead developer
Zhejiang Qianjin Pharmaceutical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Topical
01

Overview

Yuhudie Melasma Ointment is a topical Traditional Chinese Medicine (TCM) formulation developed by Hangzhou Qianjin Pharmaceutical Co., Ltd. for the treatment of melasma. The product is specifically indicated for patients whose melasma is attributed to blood stasis and deficiency according to TCM diagnostic principles. Its primary active components are derived from botanical extracts, likely including the seeds of *Oroxylum indicum* (known as Yuhudie in TCM). A Phase III clinical trial (CTR20234118) was initiated in China but was actively terminated by the sponsor to conduct a Phase IIb study and refine Phase II data, placing the current development status in Phase II.

Brand names
Yuhudie Quban Gao
Other names
玉蝴蝶祛斑膏Yuhudie Quban Gao
02

Targets

AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)TNFA (Tumor necrosis factor alpha (soluble))MAPK3 (Mitogen-activated protein kinase 1)EGFR T790M (Epidermal growth factor receptor T790M mutant)

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