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YuKuiQing
- Development stage
- Unknown
- Lead developer
- Jiangsu Provincial Hospital of Traditional Chinese Medicine
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
YuKuiQing (also known as Yu Kui Qing) is a traditional Chinese medicine (TCM) hospital preparation developed as an oral granule formulation for the treatment of early-stage type 2 diabetic nephropathy (diabetic kidney disease). It is a multi-herb formula composed of *Abelmoschus manihot* (Huang Shu Kui), *Astragalus membranaceus* (Huang Qi), and processed *Polygonum multiflorum* (Zhi Shou Wu) in a 30:1.5:1 ratio. YuKuiQing exerts reno-protective and anti-inflammatory effects by inhibiting the upregulation of advanced glycation end product (AGE)-induced chemokines, specifically monocyte chemoattractant protein-1 (MCP-1/CCL2) and fractalkine (CX3CL1), thereby reducing monocyte transmigration and adhesion to human renal mesangial cells.
- Other names
- Yu Kui QingYu Kui Qing extractYu Kui Qing granulesYuQuiQing玉葵清玉葵清浸膏玉葵清颗粒
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