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Yunnan Hongyao Capsule is a proprietary Traditional Chinese Medicine (TCM) formulation primarily used for its analgesic, anti-inflammatory, and blood-circulation-promoting properties. It is composed of several herbal extracts, including *Panax notoginseng* (Sanqi), *Carthamus tinctorius* (Safflower), *Angelica sinensis* (Danggui), and *Ligusticum chuanxiong*. Traditionally indicated for traumatic injuries, internal bleeding, and inflammatory conditions, it has been investigated by the First Affiliated Hospital of Xiamen University for the treatment of diabetic distal symmetrical polyneuropathy (DPN). Its therapeutic efficacy in DPN is attributed to its ability to improve peripheral microcirculation, enhance nerve conduction velocity, and reduce blood viscosity. The active components, particularly ginsenosides from *Panax notoginseng*, exhibit neuroprotective effects by modulating oxidative stress and inflammatory pathways.
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