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Yunpi Jiedu Tongluo Qushi Granules
- Development stage
- Preclinical
- Lead developer
- Zhejiang Chinese Medical University
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Yunpi Jiedu Tongluo Qushi Granules is a traditional Chinese medicine (TCM) multi-herbal formulation developed for the treatment of rheumatoid arthritis and related inflammatory conditions. It is used as an adjunct or alternative to conventional disease-modifying antirheumatic drugs (DMARDs), particularly in China. The granule contains a combination of herbal ingredients designed to "invigorate the spleen," "detoxify," "unblock collaterals," and "dispel dampness" according to TCM theory. Modern pharmacological studies suggest that its mechanism involves anti-inflammatory effects, including modulation of immune responses and reduction of oxidative stress. Proteomic and network pharmacology analyses have identified S100A8 as a key anti-inflammatory target, indicating that the granule may exert its therapeutic effect by downregulating pro-inflammatory mediators such as S100A8[8][9]. Clinical trials have evaluated its efficacy in rheumatoid arthritis, often in combination with Western medicines[2][7][10].
- Brand names
- Yunpi Jiedu Tongluo Qushi Granules
- Other names
- Yunpi Jiedu Tongluo Qushi Keli
02
Targets
S100A8 (S100 calcium-binding protein A8)
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