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Yunpiqiangshen
- Development stage
- Unknown
- Lead developer
- Jiangsu Provincial Hospital of Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Yunpiqiangshen is a Traditional Chinese Medicine (TCM) formula developed by the Jiangsu Province Hospital of Chinese Medicine, specifically indicated for the treatment of advanced chronic kidney disease (CKD), including stage 5 (end-stage renal disease). The formula is designed based on the TCM principles of "invigorating the spleen" (Yunpi) and "tonifying the kidney" (Qiangshen) to address the systemic deficiencies and toxin accumulation associated with renal failure. Pharmacologically, it is thought to slow the progression of renal fibrosis and protect residual renal function by modulating the gut-kidney axis, reducing oxidative stress, and inhibiting pro-inflammatory and pro-fibrotic signaling pathways. Clinical studies conducted at the developing institution have demonstrated its potential to improve renal function markers, reduce uremic toxins, and enhance the quality of life in patients, including those undergoing maintenance dialysis.
- Other names
- Yunpi Qiangshen FormulaYunpi Qiangshen DecoctionYunpi Qiangshen FangYPQS
02
Targets
TGFB1 (Transforming growth factor Beta-1 proprotein)
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