Drug intelligence / Profile preview

Yushuda Tablets

Development stage
Unknown
Lead developer
Sinopharm Group Tongjitang Pharmaceutical
Administration
Oral
01

Overview

**Yushuda Tablets** is an orally administered, investigational Chinese herbal medicine formulation for mild-to-moderate major depressive disorder, specifically patients characterized in traditional Chinese medicine as having dampness/turbidity obstructing the spleen with qi stagnation. The formula is reported to include cablin patchouli, tangerine peel, katsumadai seed, and atractylodes rhizome. It is intended to relieve depressive symptoms through the traditional therapeutic principles of awakening the spleen, resolving dampness, regulating qi, and relieving depression; a discrete molecular target-based mechanism has not been publicly established. A randomized, double-blind, placebo-controlled multicenter Phase III study was completed, and its Chinese marketing application was accepted in June 2025. ([chinadrugtrials.org.cn](https://www.chinadrugtrials.org.cn/clinicaltrials.searchlist.dhtml?keywords=CTR20222691))

Other names
YushudaYushuda TabletYushuda Tablets五味藿香片郁枢达片
02

Targets

SERT (Sodium-dependent serotonin transporter)HTR2A (Serotonin receptor 5-HT2A)DAT (Dopamine plasma membrane transport protein)Cyp (Cyclophilin family)NET (Norepinephrine Transporter)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))

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