Drug intelligence / Profile preview

Yuxuebi

Development stage
Phase 4
Lead developer
China Resources Benxi Sanyao
Modality
Small Molecules
Administration
Oral
01

Overview

Yuxuebi (YXB) is a Chinese patent medicine formulated as an oral tablet and used primarily in traditional Chinese medicine for the treatment of "Bi" syndrome, which includes conditions such as rheumatoid arthritis, osteoarthritis, scleroderma, and ankylosing spondylitis. It is known for its effects in activating blood circulation, dissipating blood stasis, relieving pain, and reducing inflammation. Pharmacological studies have shown that YXB exerts anti-inflammatory effects by inhibiting key inflammatory mediators such as TNF-α, IL-1β, IL-6, COX-2 (PTGS2), and signaling pathways including NF-κB (RELA), MAPK1/8/14 (ERK1/2/JNK/p38). Additionally, YXB has demonstrated analgesic properties similar to non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids and may also modulate ion channel activity relevant to neuropathic pain. The product contains multiple active compounds with synergistic effects on these targets[1][2][5][6].

Brand names
yuxuebi tablet
Other names
yuxuebiyxbyuxuebi tablet
02

Targets

JNK (Mitogen-activated protein kinase kinase kinase family)IL-6 (Interleukin 6)MAPK3 (Mitogen-activated protein kinase 1)RELA (Nuclear Factor Kappa B Subunit p65)TNFA (Tumor necrosis factor alpha (soluble))IL1B (Interleukin-1 beta)MAPK14 (p38 mitogen-activated protein kinase alpha)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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