Drug intelligence / Profile preview

Yuzhuo Zhixiao Pill

Development stage: Preclinical
Lead developer: Beijing University of Chinese Medicine
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Small Molecules, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

Yuzhuo Zhixiao Pill (YZZXP) is a multi-herb Traditional Chinese Medicine (TCM) formulation investigated for the treatment of non-alcoholic steatohepatitis (NASH). It is typically composed of seven botanical ingredients: *Coptis chinensis*, *Pueraria lobata*, *Salvia miltiorrhiza*, *Crataegus pinnatifida*, *Alisma plantago-aquatica*, *Prunus persica*, and *Rheum palmatum*. The therapeutic mechanism of YZZXP involves the modulation of the gut microbiota-bile acid-short-chain fatty acid (GM-BA-SCFA) axis. By restructuring the gut microbial community, the formulation influences bile acid signaling and enhances the production of short-chain fatty acids, which collectively work to reduce hepatic fat accumulation, inflammation, and metabolic dysfunction. It is primarily researched for its potential to address the multifactorial etiology of NASH with a favorable safety profile compared to conventional pharmacological interventions.

Brand names: YZZXP
Other names: Yuzhuo Zhixiao Wan

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