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YX968
- Development stage
- Unknown
- Lead developer
- University of Florida
- Modality
- PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
01
Overview
YX968: sourced facts only. name: "Here, we report a novel HDAC3/8 dual degrader YX968 that induces highly potent, rapid, and selective degradation of both HDAC3/8 without triggering pan-HDAC inhibitory effects." [PMID:37572669]; target: "Here, we report a novel HDAC3/8 dual degrader YX968 that induces highly potent, rapid, and selective degradation of both HDAC3/8 without triggering pan-HDAC inhibitory effects." [PMID:37572669]; developer: "Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA." [PMID:37572669]; modality: "Here, we report a novel HDAC3/8 dual degrader YX968 that induces highly potent, rapid, and selective degradation of both HDAC3/8 without triggering pan-HDAC inhibitory effects." [PMID:37572669]; stage: "YX968 promotes apoptosis and kills cancer cells with a high potency in vitro." [PMID:37572669]
02
Targets
HDAC3 (Histone Deacetylase 3)
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