z-ligustilide

Z-ligustilide is a natural phthalide compound, specifically an enol ester and benzoquinone derivative, found in various traditional Chinese medicinal plants, most notably Angelica sinensis (Danggui) and Ligusticum chuanxiong. It exhibits a range of pharmacological activities including neuroprotection, antioxidant, anti-inflammatory, and anticancer properties. Mechanistically, it is neuroprotective by activating the Nrf2-TrxR signaling axis, which promotes endogenous antioxidant capacity and drives microglial polarization toward the M2 (anti-inflammatory) phenotype, providing benefit in models of Parkinson's disease. In cancer cells, it induces apoptosis via ER stress signaling, c-Myc activation, and modulation of NRF2-related pathways. Preclinical studies indicate additional effects in models of depression, osteoarthritis, and inflammation, but Z-ligustilide is not an approved pharmaceutical and is primarily used in research or as a constituent of traditional herbal formulations[1][3][4][6][7].

Other names

cis-ligustilide(Z)-3-butylidene-4,5-dihydroisobenzofuran-1(3H)-oneLigustilide AZ-Ligustilide-RMLigustilideZ-(In Acetonitrile)(P)(Z)-Ligustilide (Chloroform Solution)Z-Ligustilide (50 mg) (COLD SHIPMENT)LIGUSTILIDEZ-[~10mg/ML IN ACETONITRILE(3Z)-3-butylidene-4,5-dihydro-2-benzofuran-1-one