z-val-ala-asp fluoromethyl ketone

Z-Val-Ala-Asp fluoromethyl ketone (commonly abbreviated as Z-VAD-FMK) is a synthetic small molecule that acts as a non-methylated, competitive, and irreversible inhibitor of caspase 1 (also known as interleukin 1 beta-converting enzyme or ICE), as well as other caspases. It is widely used in research to inhibit apoptosis by blocking the activity of caspases, which are key mediators of programmed cell death. Unlike some related compounds, it does not require an esterase for activation and can be used directly with purified enzymes. It is considered a pan-caspase inhibitor due to its broad activity against multiple caspase family members. Its primary use is experimental and investigational; it has not been approved for clinical use in humans[2][3][4][5][9].

Brand names

C2105C-2105C 2105

Other names

N-[(Benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxo-2-butanyl]-L-alaninamidebenzyloxycarbonyl-Val-Ala-DL-Asp-fluoromethylketoneCbz-Val-Ala-DL-Asp-CH2FCbz-Val-Ala-DL-Asp-CH-2FCbz-Val-Ala-DL-Asp-CH 2F