Drug intelligence / Profile preview

zaleplon

Development stage
Approved
Lead developer
Pfizer
Modality
Small Molecules
Administration
Oral
01

Overview

Zaleplon is a nonbenzodiazepine hypnotic of the pyrazolopyrimidine class, primarily indicated for the short-term treatment of insomnia. It acts as a sedative by selectively binding to benzodiazepine sites on the alpha-1 subunit of the GABA-A receptor complex in the central nervous system, enhancing GABAergic inhibition and promoting sleep onset. Unlike traditional benzodiazepines, zaleplon has minimal effects on sleep architecture and is considered an ultrashort-acting agent. It was developed by King Pharmaceuticals[5][3][6].

Brand names
Sonata
02

Targets

GABRA1 (Gamma-aminobutyric acid type A receptor alpha 1 subunit)GABRA2 (Gamma-aminobutyric acid receptor subunit alpha 2)GABRA3 (Gamma-aminobutyric acid receptor subunit alpha-3)

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