zaltoprofen

Zaltoprofen is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class, approved for use in Japan since 1993 and used primarily in several Asian countries[1][2][3]. It is indicated for the management of pain and inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, low back pain, frozen shoulder, neck–shoulder–arm syndrome, headaches, dental pain and other musculoskeletal disorders[4][5]. Zaltoprofen acts mainly as a preferential cyclooxygenase‐2 (COX‐2) inhibitor that blocks prostaglandin biosynthesis in the arachidonic acid pathway to reduce inflammation and pain[6]. Additionally, it exhibits unique pharmacological activity by inhibiting bradykinin-induced nociception through blockade of the B₂ receptor-mediated pathway in primary sensory neurons—an effect not shared by all NSAIDs—which may contribute to its potent analgesic properties[6][8]. Zaltoprofen has also demonstrated membrane stabilizing actions such as inhibition of leukocyte migration and lysosomal enzyme release. It is generally well tolerated with fewer gastrointestinal side effects compared to some other NSAIDs[7].

Brand names

Soleton

Other names

zaltoprofenezaltoprofenozaltoprofenum2-(10-oxo-10,11-dihydrodibenzo[b,f]thiepin-2-yl)propanoic acid