Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
zastaprazan
- Development stage
- Phase 4
- Lead developer
- Onconic Therapeutics
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Zastaprazan (JP-1366) is a novel, orally administered small molecule drug classified as a potassium-competitive acid blocker (P-CAB). It acts by selectively and potently inhibiting the gastric H+/K+-ATPase enzyme in parietal cells of the stomach, thereby suppressing gastric acid secretion. This mechanism is distinct from traditional proton pump inhibitors and results in rapid and sustained acid suppression. Zastaprazan has demonstrated superior efficacy compared to other P-CABs such as TAK-438 in preclinical models of gastroesophageal reflux disease (GERD), erosive esophagitis, and gastric/peptic ulcers. The drug was developed by Onconic Therapeutics and is approved for erosive esophagitis in South Korea as of 2024. It has also reached phase III clinical trials for indications including gastric ulcer and peptic ulcer[1][2][5][6][8].
- Brand names
- JAQBO
- Other names
- zastaprazan citrate
02
Targets
ATP4A (Potassium–transporting ATPase alpha chain 1)
Beyond the preview
Go deeper on zastaprazan.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on zastaprazan.