ZCL367

ZCL367 is a **small molecule inhibitor** that selectively inhibits the interaction between **cell division control protein 42 homolog (Cdc42)** and its effector protein **intersectin**. Cdc42 is a member of the Rho family of small GTPases, known to regulate key processes in cell cycle progression, cell proliferation, migration, and cytoskeleton remodeling, and is implicated in multiple cancers. ZCL367 showed increased potency and selectivity for Cdc42 over closely related GTPases (Rac1, RhoA). In preclinical studies, ZCL367 has been shown to impede cancer cell cycle progression, proliferation, migration, filopodia formation, and to reduce tumorigenesis in xenograft models, particularly in **lung and prostate cancer** cell lines. ZCL367 is considered a strong candidate for anticancer drug lead optimization and further studies[1][3][7].

Other names

ZCL367ZCL-367ZCL 367