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ZCPHs

Development stage: Preclinical
Lead developer: Harbin Medical University
Modality: Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Small Molecules, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems
Administration: Intravenous

Overview

ZCPHs is an experimental multifunctional nanoplatform developed for the treatment of ovarian cancer. It is composed of a zeolitic imidazolate framework-8 (ZIF-8) metal-organic framework (MOF) core co-loaded with polyoxometalates (POMs) and chloroquine diphosphate (CQ), and encapsulated within a hyaluronic acid (HA) shell. The platform is designed for synergistic therapy: the POMs act as photothermal agents that generate heat under 808 nm near-infrared (NIR) laser irradiation to induce cancer cell necrosis, while also functioning as antioxidants by scavenging reactive oxygen species (ROS) to mitigate therapy-induced inflammation. Chloroquine is included to inhibit autophagy, a self-protection mechanism in cancer cells that can lead to therapy resistance. The hyaluronic acid coating provides active targeting to CD44-overexpressing tumor cells and improves the stability of the nanostructure.

Other names: ZIF-8/CQ/POM/HA nanoplatform

Targets

CD44 (CD44 antigen)Neuraminidase

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