ZD6126

ZD6126 is a vascular-targeting agent and a water-soluble phosphate prodrug of N-acetylcolchinol, structurally related to colchicine. It acts as a vascular disrupting agent (VDA) by binding to and destabilizing the tubulin cytoskeleton in proliferating endothelial cells of tumor blood vessels, leading to selective occlusion of tumor vasculature, cessation of tumor blood flow, and extensive central tumor necrosis. Unlike other tubulin-binding agents that act primarily through mitotic arrest, ZD6126 induces rapid morphological changes in immature endothelial cells at noncytotoxic concentrations. The drug was developed for the treatment of solid tumors such as metastatic renal cell carcinoma and metastatic colorectal cancer but was discontinued due to significant cardiotoxicity observed in clinical trials[1][3][4][5][7][8].

Other names

N-Acetylcolchicinol dihydrogenphosphateN-Acetylcochinol-O-phosphate