Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
ZD7114
- Development stage
- Discontinued
- Lead developer
- AkzoNobel
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
ZD7114 (also known as ICI D7114) is a selective beta-3 adrenergic receptor agonist originally developed by Imperial Chemical Industries (ICI) and Zeneca (now AstraZeneca) for the treatment of obesity and type 2 diabetes (non-insulin-dependent diabetes mellitus). It acts by stimulating thermogenesis and lipolysis in brown adipose tissue (BAT). Although ZD7114 demonstrated potent thermogenic and anti-obesity effects in rodent models, clinical trials in humans failed to show significant increases in energy expenditure or weight loss, leading to the discontinuation of its clinical development. Additionally, ZD7114 has been shown to exhibit off-target alpha-1 adrenergic receptor antagonism in human prostate smooth muscle.
- Other names
- (S)-4-[2-hydroxy-3-phenoxypropylaminoethoxy]-N-(2-methoxyethyl)phenoxyacetamideICI-D 7114ICI-D7114ICI-D-7114ZD-7114ZD7114ZD 7114ZD-7114 hydrochlorideZD7114 hydrochlorideZD 7114 hydrochlorideZD7114 HClZD-7114 HClZD 7114 HCl
02
Targets
ADRB3 (β3)
Beyond the preview
Go deeper on ZD7114.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on ZD7114.