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ZE77-0273
- Development stage
- Preclinical
- Lead developer
- Eilean Therapeutics
- Modality
- Small Molecules
- Administration
- Not Specified
01
Overview
ZE77-0273 is a reversible small-molecule drug candidate developed by Eilean Therapeutics. It acts as a pan-EGFR inhibitor, demonstrating broad activity against resistance mutations in EGFR-mutant non-small cell lung cancer (NSCLC) and has a high selectivity index versus wild-type EGFR. It is designed to be brain- and lung-permeable, offering an excellent safety and tolerability profile[1][8].
- Brand names
- ZE77-0273ZE-77-0273ZE 77-0273
- Other names
- ZE77-0273ZE-77-0273ZE 77-0273
02
Targets
EGFR T790M (Epidermal growth factor receptor T790M mutant)
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