Drug intelligence / Profile preview

Zecuity

Development stage
Approved
Lead developer
Teva Pharmaceutical Industries
Modality
Small Molecules
Administration
Transdermal
01

Overview

Zecuity is a sumatriptan-based iontophoretic transdermal system developed by NuPathe and later acquired by Teva for the acute treatment of migraine with or without aura in adults. It consists of a single-use, battery-powered patch that utilizes a low-level electrical current (iontophoresis) to deliver 6.5 mg of sumatriptan succinate through the skin over a 4-hour period. This delivery method bypasses the gastrointestinal tract, making it a suitable option for patients who experience migraine-related nausea or vomiting. Although approved by the FDA in January 2013, Teva voluntarily suspended sales and distribution of the product in 2016 following reports of serious application-site reactions, including skin burns and scarring.

Brand names
Zecuity
Other names
sumatriptan iontophoretic transdermal systemsumatriptan succinate iontophoretic transdermal patch
02

Targets

HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR1B (5-Hydroxytryptamine Receptor 1B)HTR1D (5-hydroxytryptamine receptor 1D)

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