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Zedoary turmeric oil is a volatile essential oil extracted from the rhizome of Curcuma zedoaria (zedoary), a plant in the ginger family. It is used in traditional medicine and as an ingredient in some pharmaceutical preparations. The oil contains various bioactive compounds with reported anti-inflammatory[2][6], antimicrobial[1], antiviral[3], and antitumor properties[5]. Mechanistically, it has been shown to induce apoptosis and senescence in cancer cells by upregulating proteins such as p16, p21, and p53 and activating ERK phosphorylation pathways[5]. In clinical settings—particularly in China—it is used as an injectable preparation for conditions like viral encephalitis (often combined with ganciclovir and interferon)[3] and acute lung injury/respiratory inflammation[2][6]. It also has applications for digestive complaints (colic, indigestion), pain relief (including arthritis), gynecological diseases such as vulvitis or colpitis[7], mosquito repellent use when applied topically[1], and emotional wellness via aromatherapy. Its broad pharmacological actions are attributed to its complex mixture of sesquiterpenes and other phytochemicals.
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