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Drug intelligence / Profile preview
Zeotone Plus
- Development stage
- Unknown
- Lead developer
- AVN Ayurveda Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Zeotone Plus is a polyherbal Ayurvedic formulation developed by AVN Ayurveda Pharmaceuticals for the treatment of osteoarthritis. Administered orally as a soft gel capsule, it contains a synergistic blend of ingredients including Gandha Tailam (a proprietary sesame oil processed with herbs), Cissus quadrangularis, Shallaki (Boswellia serrata), Guggulu (Commiphora wightii), Haridra (Curcuma longa), and Shanka Bhasma. The formulation targets multiple inflammatory pathways by inhibiting Interleukin-1 (IL-1), Nuclear Factor-kappa B (NF-kB), Interleukin-6 (IL-6), 5-Lipoxygenase (5-LOX), Cyclooxygenase-2 (COX-2), and Tumor Necrosis Factor-alpha (TNF-alpha). It also inhibits matrix metalloproteinases (MMPs) to protect cartilage and promotes the production of endogenous polyunsaturated fatty acids (PUFAs) to support joint health. Clinical trials have shown Zeotone Plus to be significantly more effective than the combination of glucosamine and chondroitin in reducing pain and improving functional mobility in patients with osteoarthritis.
- Brand names
- Zeotone PlusZeotone
- Other names
- Polyherbal OA formulationPolyherbal Formulation (Osteoarthritis)
02
Targets
ALOX5 (Arachidonate 5-lipoxygenase)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)IL1A (Interleukin 1 alpha)IL-6 (Interleukin 6)NF-κBTNFA (Tumor necrosis factor alpha (soluble))MMP12 (Macrophage Metalloelastase)
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