Drug intelligence / Profile preview

Zepitan

Development stage
Preclinical
Lead developer
Provident Pharmaceuticals
Modality
Small Molecules
Administration
Oral
01

Overview

**Zepitan** is an upcoming oral fixed-dose combination of **pitavastatin** and **ezetimibe** from Provident Pharmaceuticals for dyslipidemia. The product is listed as film-coated tablets containing pitavastatin 1 mg, 2 mg, or 4 mg plus ezetimibe 10 mg. Pitavastatin inhibits 3-hydroxy-3-methylglutaryl-coenzyme A reductase to reduce hepatic cholesterol synthesis, while ezetimibe inhibits the intestinal sterol transporter Niemann-Pick C1-like protein 1 to reduce dietary and biliary cholesterol absorption. ([providentpharma.gr](https://www.providentpharma.gr/en/pharmaceutical-products))

Brand names
Zepitan
Other names
ezetimibe + pitavastatinpitavastatin + ezetimibe
02

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)NPC1L1 (Niemann-pick C1-Like 1 transporter)

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