zerumbone

**Zerumbone** is a natural monocyclic sesquiterpene (phytochemical cyclic ketone) primarily isolated from the rhizomes of *Zingiber zerumbet* (a ginger of the Zingiberaceae family)[2][7]. It displays a broad spectrum of biological activities: antitumor (via selective apoptosis of various cancer cell lines by upregulating TRAIL death receptors DR4/DR5 and downregulating cFLIP), antioxidant, anti-inflammatory (inhibiting lipocalin-2, production of reactive oxygen species, cytokines such as IL-6, IL-1β, TNF-α), antimicrobial, anti-nociceptive, immunomodulatory, anti-diabetic, anti-hyperlipidemic, hepatoprotective, gastroprotective, and anti-proliferative effects[1][2][3][4][7][8]. Zerumbone acts on multiple molecular pathways including NF-κB inhibition, reactive oxygen species mediation, modulation of p53, Bax, and p21, with some efficacy in preclinical models of learning/memory impairment and neuroinflammation[1][2][3]. It is highly lipophilic, with poor aqueous solubility and limited oral bioavailability, and is mostly researched for its potential as a dietary supplement and investigational drug for chronic inflammatory, neoplastic, and neurodegenerative diseases[2][6][7].

Other names

(2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-oneshampoo ginger compoundZER