Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
ZetaFuse
- Development stage
- Unknown
- Lead developer
- ZetaGen
- Modality
- Inhalation Devices → Device-based Delivery → Drug Delivery Systems, Small Molecules, Implantable Devices → Device-based Delivery → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems
- Administration
- Surgical Implantation
01
Overview
ZetaFuse is a synthetic, small-molecule-based osteoinductive biomaterial developed as a drug-device combination product for bone grafting and spinal fusion. It is designed to promote bone growth (osteoinduction), prevent bone resorption (anti-osteolytic), and inhibit tumor cell division (anti-tumorigenic). The mechanism of action involves antagonism of the opioid growth factor receptor (OGFR) pathway, targeting the management of the p21 transcript in mesenchymal stem cells to stimulate their differentiation into osteoblasts. Unlike biologic growth factors that carry higher cancer risk, ZetaFuse leverages components with established clinical safety profiles and cost-effective manufacturing. It has received FDA Breakthrough Designation for use in spinal fusion across cervical, thoracic, and lumbar regions and is being investigated for degenerative disc disease as well as metastatic cancer-related bone lesions[1][2][3][4][5][6][8].
- Brand names
- ZetaFuse
- Other names
- ZetaFuseZeta-ZF-002Zeta-ZF002Zeta-ZF 002
02
Targets
OGFR (Opioid growth factor receptor)
Beyond the preview
Go deeper on ZetaFuse.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on ZetaFuse.