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ZEToptic-N (brand name: ZEToptic™-N) is a preservative-free ophthalmic suspension developed and manufactured by Liqvor. It is a fixed-dose combination of brinzolamide (10 mg/mL), a carbonic anhydrase inhibitor, and timolol (5 mg/mL, as timolol maleate), a non-selective beta-adrenergic receptor antagonist. ZEToptic-N is indicated for the reduction of elevated intraocular pressure (IOP) in adult patients with open-angle glaucoma or ocular hypertension who are insufficiently controlled by monotherapy. By combining these two active ingredients, the medication reduces aqueous humor production through complementary mechanisms, thereby lowering intraocular pressure. The preservative-free formulation is designed to minimize corneal toxicity and ocular irritation, making it suitable for patients with sensitive eyes or pre-existing ocular surface disease.
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