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Zexie Jiangzhi Capsule
- Development stage
- Phase 1
- Lead developer
- Lianyungang Kanion
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Zexie Jiangzhi Capsule is a Traditional Chinese Medicine (TCM) pharmaceutical developed by Jiangsu Kanion Pharmaceutical Co., Ltd. for the management of hyperlipidemia. The formulation is primarily composed of an extract from the rhizome of *Alisma orientale* (Water Plantain). Its therapeutic profile is driven by bioactive triterpenoids, specifically alisols (such as Alisol A and Alisol B 23-acetate), which exert lipid-lowering effects through multiple pathways: inhibiting HMG-CoA reductase to decrease endogenous cholesterol synthesis, modulating the farnesoid X receptor (FXR) to promote bile acid excretion, and potentially inhibiting acyl-CoA cholesterol acyltransferase (ACAT) to reduce cholesterol absorption. It is clinically indicated for patients with elevated total cholesterol and triglycerides, often associated with the TCM diagnosis of phlegm-dampness accumulation.
- Brand names
- Zexie Jiangzhi Capsule
- Other names
- Zexie Jiangzhi Jiaonang泽泻降脂胶囊
02
Targets
HNF4A (Hepatocyte nuclear factor 4 alpha)NR1H3 (Liver X receptor beta)PPARA (Peroxisome proliferator-activated receptor alpha)TLR4 (Toll-like receptor 4)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)SOAT1 (Sterol O-acyltransferase)FXR (Farnesoid x-activated receptor)
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