Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
ZFPG
- Development stage
- Preclinical
- Modality
- Inorganic Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
ZFPG is an engineered nanozyme nanoparticle consisting of a ZnFe2O4@Pt core and a glucose oxidase (GOx) shell, developed for the treatment of prostate carcinoma. It utilizes a multi-modal therapeutic strategy combining cascade-enzyodynamic therapy, sonodynamic therapy, and metallo-immunotherapy. The nanoparticles exhibit five-enzyme activities and sonosensitivity, allowing them to deplete glutathione (GSH) and glucose within the tumor microenvironment while generating multiple bursts of reactive oxygen species (ROS) upon ultrasound stimulation. This oxidative stress upregulates heme oxygenase 1 (HMOX1), leading to the accumulation of ferrous ions (Fe2+) and lipid peroxides, which triggers immunogenic ferroptosis. Additionally, ZFPG NPs possess magnetic targeting properties to enhance tumor accumulation and can remodel the immunosuppressive tumor microenvironment to stimulate anti-tumor immunity and inhibit metastatic progression.
- Other names
- ZnFe2O4@Pt-GOx nanoparticles
02
Targets
HMOX1 (Heme oxygenase 1)GSH (Glutathione)
Beyond the preview
Go deeper on ZFPG.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on ZFPG.