Zhejiang Univ. AR compound C2

Zhejiang Univ. AR compound C2: sourced facts only. name: "Herein, we report the systematic structural optimizations of AT2 and discover a novel tetrahydroquinoline derivative C2 as potent AR antagonist with an IC50 value of 0.019 μM, accompanied with excellent selectivity over other nuclear receptors (PR, GR, MR)." [PMID:40188583]; target: "Herein, we report the systematic structural optimizations of AT2 and discover a novel tetrahydroquinoline derivative C2 as potent AR antagonist with an IC50 value of 0.019 μM, accompanied with excellent selectivity over other nuclear receptors (PR, GR, MR)." [PMID:40188583]; developer: "College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China." [PMID:40188583]; stage: "Further biological assays revealed that C2 significantly inhibited LNCaP cell proliferation, and efficiently reduced PSA protein expression." [PMID:40188583]