Zhejiang Univ. JOSD2 compound 31

Zhejiang Univ. JOSD2 compound 31: sourced facts only. name: "Subsequently, guided by structure-activity relationship (SAR) analysis, compound 31 was synthesized, a JOSD2 inhibitor featuring a cyanamide warhead that selectively engaged the catalytic cysteine residue." [PMID:41092805]; target: "Subsequently, guided by structure-activity relationship (SAR) analysis, compound 31 was synthesized, a JOSD2 inhibitor featuring a cyanamide warhead that selectively engaged the catalytic cysteine residue." [PMID:41092805]; developer: "Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou 310018, PR China.; Institute of Pharmacology & Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR China." [PMID:41092805]; stage: "Further mechanistic studies have shown that 31 could induce the downregulation of KRAS protein expression in HCT116 cells, thereby exerting proliferation inhibitory activity (IC50 = 0.93 ± 0.01 μM)." [PMID:41092805]