Drug intelligence / Profile preview

Zhenbing Koukuining lozenge

Development stage
Unknown
Lead developer
Wuhan Junan Pharmaceutical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Buccal
01

Overview

Zhenbing Koukuining lozenge is a Traditional Chinese Medicine (TCM) therapeutic developed by Wuhan Junan Pharmaceutical Co., Ltd. for the treatment of mild recurrent aphthous stomatitis (canker sores). Formulated as a lozenge for local administration in the oral cavity, it is specifically indicated for patients presenting with the TCM pattern of heart-spleen excess heat. The drug aims to reduce pain and accelerate the healing of oral ulcers. It has been evaluated in a randomized, double-blind, placebo-controlled Phase 2 clinical trial in China to determine its safety, efficacy, and optimal dosing regimen.

Brand names
Zhenbing Koukuining lozenge
Other names
Zhenbing Koukuining Hanpian
02

Targets

HMGB1 (High mobility group protein B1)DNA gyraseNaV (Voltage-gated sodium channels)HSD11B2 (11β-HSD2)

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