Drug intelligence / Profile preview

Zhengzhou Univ. LSD1 compound 9e

Development stage
Preclinical
Lead developer
Zhengzhou University
01

Overview

Zhengzhou Univ. LSD1 compound 9e: sourced facts only. name: "The representative compound, 9e, proved to be a highly effective LSD1 inhibitor, with an IC50 value of 9.85 nM, and demonstrated exceptional selectivity for LSD1 over both MAOs and hERG." [PMID:40022881]; target: "The representative compound, 9e, proved to be a highly effective LSD1 inhibitor, with an IC50 value of 9.85 nM, and demonstrated exceptional selectivity for LSD1 over both MAOs and hERG." [PMID:40022881]; developer: "College of Chemistry, Zhengzhou University, Zhengzhou, Henan, 450001, PR China." [PMID:40022881]; stage: "compound 9e exhibited significant inhibitory activity against leukemia cells, especially MV-4-11, HL-60, and THP-1 cells, with IC50 values of 1.40, 1.54, and 1.96 μM respectively." [PMID:40022881]

02

Targets

KDM1A (LSD1)

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