Zhengzhou Univ. USP7 compound D16

Zhengzhou Univ. USP7 compound D16: sourced facts only. name: "Mechanistic investigation with specific inhibitors revealed that D16 induced USP7 degradation by binding to USP7 and E3 ligase CRBN." [PMID:41418743]; target: "Mechanistic investigation with specific inhibitors revealed that D16 induced USP7 degradation by binding to USP7 and E3 ligase CRBN." [PMID:41418743]; developer: "Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Henan Province Key Laboratory of Small Molecule Drug Discovery and Applied Research, School of Pharmaceutical Sciences, Zhengzhou University, 100 Science Avenue, Zhengzhou, 450001, China." [PMID:41418743]; modality: "In this study, we firstly designed and synthesized a panel of novel USP7 PROTACs with USP7 inhibitor containing thienopyridine, and identified D16 as a potent and selective USP7 degrader." [PMID:41418743]; stage: "Moreover, treatment of D16 suppressed cell migration of upper gastrointestinal (UGI) cancer cells with minor anti-proliferative activity." [PMID:41418743]