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Zhibai Dihuang Wan is a classic Traditional Chinese Medicine (TCM) formula derived from Liuwei Dihuang Wan with the addition of Anemarrhena asphodeloides (Zhimu) and Phellodendron amurense (Huangbai). It is primarily used to treat yin deficiency with vigorous fire (yin xu huo wang), characterized by symptoms such as night sweats, dry mouth, sore throat, and tinnitus. In clinical research, it has been investigated for its efficacy in treating recurrent oral ulcers, gingivitis, dry eye, and central precocious puberty in children. The formula works by nourishing kidney yin and clearing heat, modulating the immune and endocrine systems through its complex botanical constituents.
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