Drug intelligence / Profile preview

zhibituo

Development stage
Unknown
Lead developer
Chengdu Diao Jiuhong Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Zhibituo is a proprietary Chinese medicine containing red yeast rice (Monascus purpureus) as a main active ingredient, often formulated with other herbs. The primary therapeutic effect is lipid-lowering, working mainly through inhibition of HMG-CoA reductase, which reduces cholesterol synthesis in the liver. The main bioactive component, lovastatin (monacolin K), is identical to the statin drug lovastatin. Zhibituo is used to manage hyperlipidemia and cardiovascular risk, with studies supporting its effect in improving lipid profiles, specifically lowering LDL-C, total cholesterol, and triglycerides while increasing HDL-C. It is typically administered orally as capsules or dropping pills[1][6][7][9].

Brand names
zhibituo
Other names
Zhibituo Pian脂必妥片Red yeast rice extract
02

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)

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