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Zhiganqing
- Development stage
- Unknown
- Lead developer
- Tianjin University of Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Zhiganqing is a Traditional Chinese Medicine (TCM) formula developed by the Tianjin University of Traditional Chinese Medicine, specifically designed for the treatment of non-alcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated steatotic liver disease (MASLD). The formula is a combination of several botanical extracts, including *Alisma plantago-aquatica* (rhizome), *Crataegus pinnatifida* (fruit), *Cassia obtusifolia* (seed), *Salvia miltiorrhiza* (root), and *Nelumbo nucifera* (leaf). Zhiganqing functions by modulating lipid metabolism and reducing hepatic fat accumulation, primarily through the activation of the SIRT1/AMPK signaling pathway and the regulation of PPAR-alpha. It also demonstrates anti-inflammatory and antioxidant properties, which help mitigate liver injury and prevent the progression of steatosis to steatohepatitis (NASH).
- Brand names
- Zhiganqing
- Other names
- Zhiganqing capsuleZhiganqing formula脂肝清
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)PPARA (Peroxisome proliferator-activated receptor alpha)SIRT1 (NAD-dependent protein deacetylase sirtuin-1)
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