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Zhigen Toutongan
- Development stage
- Unknown
- Lead developer
- Shandong New Era Pharmaceutical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Zhigen Toutongan is a Traditional Chinese Medicine (TCM) capsule developed by Shandong New Era Pharmaceutical, a subsidiary of Lunan Pharmaceutical Group, for the prophylactic treatment of migraine. It is currently undergoing Phase III clinical evaluation in China (e.g., trial CTR20250990) to assess its efficacy and safety in reducing the frequency and severity of migraine attacks compared to placebo. As a botanical formulation, it likely utilizes a multi-component approach to modulate neurovascular pathways and inflammatory responses associated with migraine pathogenesis, though its specific active ingredients are typically proprietary mixtures of traditional herbs.
- Brand names
- Zhigen Toutongan Capsule
- Other names
- Zhigen Toutong An
02
Targets
5-HT (Serotonin receptors)CGRP (Calcitonin gene-related peptide)EDNRA (Endothelin receptor type A)
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