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Zhike Shuangjie is a Traditional Chinese Medicine (TCM) formulation developed by Guang'anmen Hospital of the China Academy of Chinese Medical Sciences. It is an oral powder indicated for the treatment of adult upper respiratory tract infections (URTI), specifically targeting URTI-related cough during the winter and spring seasons. The drug is being evaluated in the SMART trial (Phase 0), which compares its efficacy and safety against other TCM formulations (Zhike Baidu powder, Wensan tincture) and the leukotriene receptor antagonist montelukast sodium. As a TCM product, it likely contains a blend of botanical ingredients intended to clear heat, resolve exterior symptoms, and suppress cough.
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