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Zhongbao No.1 microRNA hydrogel
- Development stage
- Preclinical
- Lead developer
- Shanghai Skin Disease Hospital
- Modality
- RNA Therapeutics → Nucleic Acid Therapeutics, Hydrogel Systems → Drug Delivery Systems
- Administration
- Topical
01
Overview
Zhongbao No.1 microRNA hydrogel is an experimental topical RNA-based therapeutic developed by Shanghai Skin Disease Hospital for the treatment of eczema and atopic dermatitis. This formulation utilizes a specialized hydrogel delivery system to stabilize and transport microRNA (miRNA) molecules—specifically inhibitors targeting pro-inflammatory miRNAs like miR-155—into the skin's dermal layers. By modulating the expression of genes involved in Th2-mediated inflammation, the hydrogel aims to reduce skin lesions, itching, and inflammatory cell infiltration. It represents a high-tech evolution of the hospital's established "Zhongbao" line of dermatological preparations, designed to offer a targeted alternative to conventional topical steroids with potentially fewer systemic side effects.
- Brand names
- Zhongbao No.1
- Other names
- Zhongbao No. 1 microRNA hydrogel中宝1号微小RNA凝胶
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